ADAMTS13 and VWF activities guide individualized caplacizumab treatment in patients with aTTP
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چکیده
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modern surgical techniques in treatment of patients with cleft lip & cleft palate
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15 صفحه اولthe past hospitalization and its association with suicide attempts and ideation in patients with mdd and comparison with bmd (depressed type) group
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Expression and significance of vWF, GMP-140 and ADAMTS13 in patients with aneurysmal subarachnoid hemorrhage.
OBJECTIVE The aim of this study was to investigate the role of the von Willebrand factor (vWF) in patients with aneurysmal subarachnoid hemorrhage (aSAH), platelet membrane glycoprotein-140 (GMP-140). The aim is also to discover the expression and clinical significance of von Willebrand factor (vWF) cleaving protease (ADAMTS13). PATIENTS AND METHODS 83 patients with aSAH were selected from Ja...
متن کاملN-linked glycosylation of VWF modulates its interaction with ADAMTS13.
We examined the role of N-linked glycan structures of VWF on its interaction with ADAMTS13. PNGase F digestion followed by lectin analysis demonstrated that more than 90% of VWF N-linked glycan chains could be removed from the molecule (PNG-VWF) without disruption of its multimeric structure or its ability to bind to collagen. PNG-VWF had an approximately 4-fold increased affinity for ADAMTS13 ...
متن کاملSubsequent Response of VWF and ADAMTS13 to Aortic Valve Replacement
Normal hemostasis is maintained by well-balanced performance of many factors in plasma, blood cells, and vascular wall cells. von Willebrand factor (VWF) is one of the plasma proteins that is involved in platelet adhesion and aggregation 1). VWF is synthesized in vascular endothelial cells and megakaryocytes, starting with a 350-kDa precursor. This polypeptide dimerizes in the endoplasmic retic...
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ژورنال
عنوان ژورنال: Blood Advances
سال: 2020
ISSN: 2473-9529,2473-9537
DOI: 10.1182/bloodadvances.2020001987